Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization

The efficacy of novel monoclonal antibodies that neutralize the pro-angiogenic mediator, sphingosine-1-phosphate (S1P), were tested using in vitro and in vivo angiogenesis models, including choroidal neovascularization (CNV) induced by laser disruption of Bruch’s membrane. S1P receptor levels in hum...

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Detalhes bibliográficos
Main Authors: Caballero, Sergio, Swaney, James, Moreno, Kelli, Afzal, Aqeela, Kielczewski, Jennifer, Stoller, Glenn, Cavalli, Amy, Garland, William, Hansen, Geneviève, Sabbadini, Roger, Grant, Maria B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756152/
https://ncbi.nlm.nih.gov/pubmed/18723015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2008.07.012
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