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Blockade of Sphingosine-1-phosphate Reduces Macrophage Influx and Retinal and Choroidal Neovascularization

Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that stimulates endothelial cell migration, proliferation, and survival in vitro, and tumor angiogenesis in vivo. In this study, we used a humanized monoclonal antibody (sonepcizumab) that selectively binds S1P to investigate its role in re...

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Main Authors: Xie, Bing, Shen, Jikui, Dong, Aling, Rashid, Aymen, Stoller, Glenn, Campochiaro, Peter A.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905312/
https://ncbi.nlm.nih.gov/pubmed/18781584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21588
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