The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen

The pleiotropic signaling lipid sphingosine-1-phosphate (S1P) plays significant roles in angiogenesis, heart disease, and cancer. LT1009 (also known as sonepcizumab) is a humanized monoclonal antibody that binds S1P with high affinity and specificity. Because the antibody is currently in clinical tr...

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Bibliographic Details
Main Authors: Wojciak, Jonathan M., Zhu, Norman, Schuerenberg, Karen T., Moreno, Kelli, Shestowsky, William S., Hiraiwa, Masao, Sabbadini, Roger, Huxford, Tom
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764929/
https://ncbi.nlm.nih.gov/pubmed/19815502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906153106
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