Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo: Fourth in review series on chromatin dynamics

Por Urnov, Fyodor D., Rebar, Edward J., Reik, Andreas, Pandolfi, Pier Paolo
Publicado em 2002

PPARγ knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis

Por Ren, Delin, Collingwood, Trevor N., Rebar, Edward J., Wolffe, Alan P., Camp, Heidi S.
Publicado em 2002

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

Por Gammage, Payam A, Rorbach, Joanna, Vincent, Anna I, Rebar, Edward J, Minczuk, Michal
Publicado em 2014

Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing

Por Oakes, Benjamin L., Xia, Danny F., Rowland, Elizabeth F., Xu, Denise J., Ankoudinova, Irina, Borchardt, Jennifer S., Zhang, Lei, Li, Patrick, Miller, Jeffrey C., Rebar, Edward J., Noyes, Marcus B.
Publicado no Nat Commun (2016)

Site-Specific Editing of the Plasmodium falciparum Genome Using Engineered Zinc-Finger Nucleases

Por Straimer, Judith, Lee, Marcus CS, Lee, Andrew H, Zeitler, Bryan, Williams, April E, Pearl, Jocelynn R, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Llinás, Manuel, Urnov, Fyodor D, Fidock, David A
Publicado em 2012

An Engineered Zinc Finger Protein Activator of the Endogenous Glial Cell Line-Derived Neurotrophic Factor Gene Provides Functional Neuroprotection in a Rat Model of Parkinson's Dis...

Por Laganiere, Josee, Kells, Adrian P., Lai, Jeffrey T., Guschin, Dmitry, Paschon, David E., Meng, Xiangdong, Fong, Lauren K., Yu, Qi, Rebar, Edward J., Gregory, Philip D., Bankiewicz, Krystof S., Forsayeth, John, Zhang, H. Steve
Publicado no J Neurosci (2010)

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

Por Simsek, Deniz, Brunet, Erika, Wong, Sunnie Yan-Wai, Katyal, Sachin, Gao, Yankun, McKinnon, Peter J., Lou, Jacqueline, Zhang, Lei, Li, James, Rebar, Edward J., Gregory, Philip D., Holmes, Michael C., Jasin, Maria
Publicado em 2011

Mammalian interspecies substitution of immune modulatory alleles by genome editing

Por Lillico, Simon G., Proudfoot, Chris, King, Tim J., Tan, Wenfang, Zhang, Lei, Mardjuki, Rachel, Paschon, David E., Rebar, Edward J., Urnov, Fyodor D., Mileham, Alan J., McLaren, David G., Whitelaw, C. Bruce A.
Publicado no Sci Rep (2016)

Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases

Por Santiago, Yolanda, Chan, Edmond, Liu, Pei-Qi, Orlando, Salvatore, Zhang, Lin, Urnov, Fyodor D., Holmes, Michael C., Guschin, Dmitry, Waite, Adam, Miller, Jeffrey C., Rebar, Edward J., Gregory, Philip D., Klug, Aaron, Collingwood, Trevor N.
Publicado em 2008

Heritable Targeted Gene Disruption in Zebrafish Using Designed Zinc Finger Nucleases

Por Doyon, Yannick, McCammon, Jasmine M, Miller, Jeffrey C, Faraji, Farhoud, Ngo, Catherine, Katibah, George E, Amora, Rainier, Hocking, Toby D, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Urnov, Fyodor D, Amacher, Sharon L
Publicado em 2008

Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

Por Peterson, Christopher W., Wang, Jianbin, Norman, Krystin K., Norgaard, Zachary K., Humbert, Olivier, Tse, Collette K., Yan, Jenny J., Trimble, Richard G., Shivak, David A., Rebar, Edward J., Gregory, Philip D., Holmes, Michael C., Kiem, Hans-Peter
Publicado no Blood (2016)

Targeted Genome Editing Across Species Using ZFNs and TALENs

Por Wood, Andrew J., Lo, Te-Wen, Zeitler, Bryan, Pickle, Catherine S., Ralston, Edward J., Lee, Andrew H., Amora, Rainier, Miller, Jeffrey C., Leung, Elo, Meng, Xiangdong, Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Meyer, Barbara J.
Publicado em 2011

A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart

Por Zhang, H Steve, Liu, Dingang, Huang, Yan, Schmidt, Stefan, Hickey, Reed, Guschin, Dmitry, Su, Haili, Jovin, Ion S, Kunis, Mike, Hinkley, Sarah, Liang, Yuxin, Hinh, Linda, Spratt, S Kaye, Case, Casey C, Rebar, Edward J, Ehrlich, Barbara, Gregory, Philip D, Giordano, Frank J
Publicado em 2012

Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells

Por Forster, Ryan, Chiba, Kunitoshi, Schaeffer, Lorian, Regalado, Samuel G., Lai, Christine S., Gao, Qing, Kiani, Samira, Farin, Henner F., Clevers, Hans, Cost, Gregory J., Chan, Andy, Rebar, Edward J., Urnov, Fyodor D., Gregory, Philip D., Pachter, Lior, Jaenisch, Rudolf, Hockemeyer, Dirk
Publicado em 2014

Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells

Por Forster, Ryan, Chiba, Kunitoshi, Schaeffer, Lorian, Regalado, Samuel G., Lai, Christine S., Gao, Qing, Kiani, Samira, Farin, Henner F., Clevers, Hans, Cost, Gregory J., Chan, Andy, Rebar, Edward J., Urnov, Fyodor D., Gregory, Philip D., Pachter, Lior, Jaenisch, Rudolf, Hockemeyer, Dirk
Publicado em 2014

Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases

Por Young, John J., Cherone, Jennifer M., Doyon, Yannick, Ankoudinova, Irina, Faraji, Farhoud M., Lee, Andrew H., Ngo, Catherine, Guschin, Dmitry Y., Paschon, David E., Miller, Jeffrey C., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Harland, Richard M., Zeitler, Bryan
Publicado em 2011

Highly efficient gene targeting of expressed and silent genes in human ESCs and iPSCs using zinc finger nucleases

Por Hockemeyer, Dirk, Soldner, Frank, Beard, Caroline, Gao, Qing, Mitalipova, Maisam, DeKelver, Russell C., Katibah, George E., Amora, Ranier, Boydston, Elizabeth A., Zeitler, Bryan, Meng, Xiangdong, Miller, Jeffrey C., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Jaenisch, Rudolf
Publicado em 2009

Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells

Por Doyon, Jeffrey B., Zeitler, Bryan, Cheng, Jackie, Cheng, Aaron T., Cherone, Jennifer M., Santiago, Yolanda, Lee, Andrew H., Vo, Thuy D., Doyon, Yannick, Miller, Jeffrey C., Paschon, David E., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Drubin, David G.
Publicado em 2011

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

Por Sharma, Rajiv, Anguela, Xavier M., Doyon, Yannick, Wechsler, Thomas, DeKelver, Russell C., Sproul, Scott, Paschon, David E., Miller, Jeffrey C., Davidson, Robert J., Shivak, David, Zhou, Shangzhen, Rieders, Julianne, Gregory, Philip D., Holmes, Michael C., Rebar, Edward J., High, Katherine A.
Publicado no Blood (2015)

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo

Por Gammage, Payam A., Viscomi, Carlo, Simard, Marie-Lune, Costa, Ana S.H., Gaude, Edoardo, Powell, Christopher A., Van Haute, Lindsey, McCann, Beverly J., Rebelo-Guiomar, Pedro, Cerutti, Raffaele, Zhang, Lei, Rebar, Edward J., Zeviani, Massimo, Frezza, Christian, Stewart, James B., Minczuk, Michal
Publicado no Nat Med (2018)