Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases

The frog Xenopus, an important research organism in cell and developmental biology, currently lacks tools for targeted mutagenesis. Here, we address this problem by genome editing with zinc-finger nucleases (ZFNs). ZFNs directed against an eGFP transgene in Xenopus tropicalis induced mutations consi...

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Detalhes bibliográficos
Main Authors: Young, John J., Cherone, Jennifer M., Doyon, Yannick, Ankoudinova, Irina, Faraji, Farhoud M., Lee, Andrew H., Ngo, Catherine, Guschin, Dmitry Y., Paschon, David E., Miller, Jeffrey C., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Harland, Richard M., Zeitler, Bryan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084115/
https://ncbi.nlm.nih.gov/pubmed/21471457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102030108
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