Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases

The frog Xenopus, an important research organism in cell and developmental biology, currently lacks tools for targeted mutagenesis. Here, we address this problem by genome editing with zinc-finger nucleases (ZFNs). ZFNs directed against an eGFP transgene in Xenopus tropicalis induced mutations consi...

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主要な著者: Young, John J., Cherone, Jennifer M., Doyon, Yannick, Ankoudinova, Irina, Faraji, Farhoud M., Lee, Andrew H., Ngo, Catherine, Guschin, Dmitry Y., Paschon, David E., Miller, Jeffrey C., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Harland, Richard M., Zeitler, Bryan
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2011
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084115/
https://ncbi.nlm.nih.gov/pubmed/21471457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102030108
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