Heritable Targeted Gene Disruption in Zebrafish Using Designed Zinc Finger Nucleases

We describe here the use of zinc finger nucleases (ZFNs) for somatic and germline disruption of genes in zebrafish (Danio rerio), where targeted mutagenesis was previously intractable. ZFNs induce a targeted double-strand break in the genome that is repaired to generate small insertions and deletion...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Doyon, Yannick, McCammon, Jasmine M, Miller, Jeffrey C, Faraji, Farhoud, Ngo, Catherine, Katibah, George E, Amora, Rainier, Hocking, Toby D, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Urnov, Fyodor D, Amacher, Sharon L
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674762/
https://ncbi.nlm.nih.gov/pubmed/18500334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1409
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires