Highly efficient gene targeting of expressed and silent genes in human ESCs and iPSCs using zinc finger nucleases

Human embryonic stem cells and induced pluripotent stem cells (hESCs and hiPSCs) are powerful tools for biomedical research. Realizing the full potential of these cells requires efficient genetic modification. However, techniques to generate cell type specific lineage reporters as well as reliable t...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Hockemeyer, Dirk, Soldner, Frank, Beard, Caroline, Gao, Qing, Mitalipova, Maisam, DeKelver, Russell C., Katibah, George E., Amora, Ranier, Boydston, Elizabeth A., Zeitler, Bryan, Meng, Xiangdong, Miller, Jeffrey C., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Jaenisch, Rudolf
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2009
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142824/
https://ncbi.nlm.nih.gov/pubmed/19680244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1562
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