Highly efficient gene targeting of expressed and silent genes in human ESCs and iPSCs using zinc finger nucleases

Human embryonic stem cells and induced pluripotent stem cells (hESCs and hiPSCs) are powerful tools for biomedical research. Realizing the full potential of these cells requires efficient genetic modification. However, techniques to generate cell type specific lineage reporters as well as reliable t...

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Détails bibliographiques
Auteurs principaux: Hockemeyer, Dirk, Soldner, Frank, Beard, Caroline, Gao, Qing, Mitalipova, Maisam, DeKelver, Russell C., Katibah, George E., Amora, Ranier, Boydston, Elizabeth A., Zeitler, Bryan, Meng, Xiangdong, Miller, Jeffrey C., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Jaenisch, Rudolf
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142824/
https://ncbi.nlm.nih.gov/pubmed/19680244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1562
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