Highly efficient gene targeting of expressed and silent genes in human ESCs and iPSCs using zinc finger nucleases

Human embryonic stem cells and induced pluripotent stem cells (hESCs and hiPSCs) are powerful tools for biomedical research. Realizing the full potential of these cells requires efficient genetic modification. However, techniques to generate cell type specific lineage reporters as well as reliable t...

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Detalhes bibliográficos
Main Authors: Hockemeyer, Dirk, Soldner, Frank, Beard, Caroline, Gao, Qing, Mitalipova, Maisam, DeKelver, Russell C., Katibah, George E., Amora, Ranier, Boydston, Elizabeth A., Zeitler, Bryan, Meng, Xiangdong, Miller, Jeffrey C., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Jaenisch, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142824/
https://ncbi.nlm.nih.gov/pubmed/19680244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1562
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