Mouse SCNT ESCs Have Lower Somatic Mutation Load Than Syngeneic iPSCs

Ectopic expression of reprogramming factors has been widely adopted to reprogram somatic nucleus into a pluripotent state (induced pluripotent stem cells [iPSCs]). However, genetic aberrations such as somatic gene mutation in the resulting iPSCs have raised concerns regarding their clinical utility....

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Detalhes bibliográficos
Main Authors: Li, Zhe, Lu, Hongxia, Yang, Weifeng, Yong, Jun, Zhang, Zhen-ning, Zhang, Kun, Deng, Hongkui, Xu, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986627/
https://ncbi.nlm.nih.gov/pubmed/24749065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.02.005
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