RUNX1–ETO induces a type I interferon response which negatively effects t(8;21)-induced increased self-renewal and leukemia development

por DeKelver, Russell C., Lewin, Benjamin, Weng, Stephanie, Yan, Ming, Biggs, Joseph, Zhang, Dong-Er
Publicado 2013

Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential

por DeKelver, Russell C., Yan, Ming, Ahn, Eun-Young, Shia, Wei-Jong, Speck, Nancy A., Zhang, Dong-Er
Publicado 2013

Cooperation between RUNX1-ETO9a and Novel Transcriptional Partner KLF6 in Upregulation of Alox5 in Acute Myeloid Leukemia

por DeKelver, Russell C., Lewin, Benjamin, Lam, Kentson, Komeno, Yukiko, Yan, Ming, Rundle, Chandler, Lo, Miao-Chia, Zhang, Dong-Er
Publicado 2013

Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

por Moehle, Erica A., Rock, Jeremy M., Lee, Ya-Li, Jouvenot, Yann, DeKelver, Russell C., Gregory, Philip D., Urnov, Fyodor D., Holmes, Michael C.
Publicado 2007

SON Controls Cell Cycle Progression by Coordinated Regulation of RNA Splicing

por Ahn, Eun-Young, DeKelver, Russell C., Lo, Miao-Chia, Nguyen, Tuyet Ann, Matsuura, Shinobu, Boyapati, Anita, Pandit, Shatakshi, Fu, Xiang-Dong, Zhang, Dong-Er
Publicado 2011

SON Protein Regulates GATA-2 through Transcriptional Control of the MicroRNA 23a∼27a∼24-2 Cluster

por Ahn, Erin Eun-Young, Higashi, Tsunehito, Yan, Ming, Matsuura, Shinobu, Hickey, Christopher J., Lo, Miao-Chia, Shia, Wei-Jong, DeKelver, Russell C., Zhang, Dong-Er
Publicado 2013

SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing

por Komeno, Yukiko, Huang, Yi-Jou, Qiu, Jinsong, Lin, Leo, Xu, YiJun, Zhou, Yu, Chen, Liang, Monterroza, Dora D., Li, Hairi, DeKelver, Russell C., Yan, Ming, Fu, Xiang-Dong, Zhang, Dong-Er
Publicado en Mol Cell Biol (2015)

The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling

por Stoner, Samuel A., Liu, Katherine Tin Heng, Andrews, Elizabeth T., Liu, Mengdan, Arimoto, Kei-Ichiro, Yan, Ming, Davis, Amanda G., Weng, Stephanie, Dow, Michelle, Xian, Su, DeKelver, Russell C., Carter, Hannah, Zhang, Dong-Er
Publicado en Blood Cancer J (2020)

Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology

por Orlando, Salvatore J., Santiago, Yolanda, DeKelver, Russell C., Freyvert, Yevgeniy, Boydston, Elizabeth A., Moehle, Erica A., Choi, Vivian M., Gopalan, Sunita M., Lou, Jacqueline F., Li, James, Miller, Jeffrey C., Holmes, Michael C., Gregory, Philip D., Urnov, Fyodor D., Cost, Gregory J.
Publicado 2010

Highly efficient gene targeting of expressed and silent genes in human ESCs and iPSCs using zinc finger nucleases

por Hockemeyer, Dirk, Soldner, Frank, Beard, Caroline, Gao, Qing, Mitalipova, Maisam, DeKelver, Russell C., Katibah, George E., Amora, Ranier, Boydston, Elizabeth A., Zeitler, Bryan, Meng, Xiangdong, Miller, Jeffrey C., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Jaenisch, Rudolf
Publicado 2009

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

por Sharma, Rajiv, Anguela, Xavier M., Doyon, Yannick, Wechsler, Thomas, DeKelver, Russell C., Sproul, Scott, Paschon, David E., Miller, Jeffrey C., Davidson, Robert J., Shivak, David, Zhou, Shangzhen, Rieders, Julianne, Gregory, Philip D., Holmes, Michael C., Rebar, Edward J., High, Katherine A.
Publicado en Blood (2015)

Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets

por Conway, Anthony, Mendel, Matthew, Kim, Kenneth, McGovern, Kyle, Boyko, Alisa, Zhang, Lei, Miller, Jeffrey C., DeKelver, Russell C., Paschon, David E., Mui, Barbara L., Lin, Paulo J.C., Tam, Ying K., Barbosa, Chris, Redelmeier, Tom, Holmes, Michael C., Lee, Gary
Publicado en Mol Ther (2019)

Dose-Dependent Prevention of Metabolic and Neurologic Disease in Murine MPS II by ZFN-Mediated In Vivo Genome Editing

por Laoharawee, Kanut, DeKelver, Russell C., Podetz-Pedersen, Kelly M., Rohde, Michelle, Sproul, Scott, Nguyen, Hoang-Oanh, Nguyen, Tam, St. Martin, Susan J., Ou, Li, Tom, Susan, Radeke, Robert, Meyer, Kathleen E., Holmes, Michael C., Whitley, Chester B., Wechsler, Thomas, McIvor, R. Scott
Publicado en Mol Ther (2018)

ZFN-Mediated In Vivo Genome Editing Corrects Murine Hurler Syndrome

por Ou, Li, DeKelver, Russell C., Rohde, Michelle, Tom, Susan, Radeke, Robert, St. Martin, Susan J., Santiago, Yolanda, Sproul, Scott, Przybilla, Michael J., Koniar, Brenda L., Podetz-Pedersen, Kelly M., Laoharawee, Kanut, Cooksley, Renee D., Meyer, Kathleen E., Holmes, Michael C., McIvor, R. Scott, Wechsler, Thomas, Whitley, Chester B.
Publicado en Mol Ther (2019)

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

por DeKelver, Russell C., Choi, Vivian M., Moehle, Erica A., Paschon, David E., Hockemeyer, Dirk, Meijsing, Sebastiaan H., Sancak, Yasemin, Cui, Xiaoxia, Steine, Eveline J., Miller, Jeffrey C., Tam, Phillip, Bartsevich, Victor V., Meng, Xiangdong, Rupniewski, Igor, Gopalan, Sunita M., Sun, Helena C., Pitz, Kathleen J., Rock, Jeremy M., Zhang, Lei, Davis, Gregory D., Rebar, Edward J., Cheeseman, Iain M., Yamamoto, Keith R., Sabatini, David M., Jaenisch, Rudolf, Gregory, Philip D., Urnov, Fyodor D.
Publicado 2010

Distinct factors control histone variant H3.3 localization at specific genomic regions

por Goldberg, Aaron D., Banaszynski, Laura A., Noh, Kyung-Min, Lewis, Peter W., Elsaesser, Simon J., Stadler, Sonja, Dewell, Scott, Law, Martin, Guo, Xingyi, Li, Xuan, Wen, Duancheng, Chapgier, Ariane, DeKelver, Russell C., Miller, Jeffrey C., Lee, Ya-Li, Boydston, Elizabeth A., Holmes, Michael C., Gregory, Philip D., Greally, John M., Rafii, Shahin, Yang, Chingwen, Scambler, Peter J., Garrick, David, Gibbons, Richard J., Higgs, Douglas R., Cristea, Ileana M., Urnov, Fyodor D., Zheng, Deyou, Allis, C. David
Publicado 2010