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Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology
We previously demonstrated high-frequency, targeted DNA addition mediated by the homology-directed DNA repair pathway. This method uses a zinc-finger nuclease (ZFN) to create a site-specific double-strand break (DSB) that facilitates copying of genetic information into the chromosome from an exogeno...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2926620/ https://ncbi.nlm.nih.gov/pubmed/20530528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq512 |
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