Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology

We previously demonstrated high-frequency, targeted DNA addition mediated by the homology-directed DNA repair pathway. This method uses a zinc-finger nuclease (ZFN) to create a site-specific double-strand break (DSB) that facilitates copying of genetic information into the chromosome from an exogeno...

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Bibliografische gegevens
Hoofdauteurs: Orlando, Salvatore J., Santiago, Yolanda, DeKelver, Russell C., Freyvert, Yevgeniy, Boydston, Elizabeth A., Moehle, Erica A., Choi, Vivian M., Gopalan, Sunita M., Lou, Jacqueline F., Li, James, Miller, Jeffrey C., Holmes, Michael C., Gregory, Philip D., Urnov, Fyodor D., Cost, Gregory J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2010
Onderwerpen:
Methods Online
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2926620/
https://ncbi.nlm.nih.gov/pubmed/20530528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq512
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