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Knockout Rats Produced Using Designed Zinc Finger Nucleases
The toolbox of rat genetics currently lacks the ability to introduce site-directed, heritable mutations into the genome to create knockout animals. Using engineered zinc-finger nucleases (ZFNs) designed to target an integrated reporter and two endogenous rat genes, Immunoglobulin M (IgM) and Rab38,...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2831805/ https://ncbi.nlm.nih.gov/pubmed/19628861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1172447 |
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