Knockout Rats Produced Using Designed Zinc Finger Nucleases

The toolbox of rat genetics currently lacks the ability to introduce site-directed, heritable mutations into the genome to create knockout animals. Using engineered zinc-finger nucleases (ZFNs) designed to target an integrated reporter and two endogenous rat genes, Immunoglobulin M (IgM) and Rab38,...

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Main Authors: Geurts, Aron M., Cost, Gregory J., Freyvert, Yevgeniy, Zeitler, Bryan, Miller, Jeffrey C., Choi, Vivian M., Jenkins, Shirin S., Wood, Adam, Cui, Xiaoxia, Meng, Xiangdong, Vincent, Anna, Lam, Stephen, Michalkiewicz, Mieczyslaw, Schilling, Rebecca, Foeckler, Jamie, Kalloway, Shawn, Weiler, Hartmut, Ménoret, Séverine, Anegon, Ignacio, Davis, Gregory D., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Jacob, Howard J., Buelow, Roland
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831805/
https://ncbi.nlm.nih.gov/pubmed/19628861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1172447
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