Knockout Rats Produced Using Designed Zinc Finger Nucleases

The toolbox of rat genetics currently lacks the ability to introduce site-directed, heritable mutations into the genome to create knockout animals. Using engineered zinc-finger nucleases (ZFNs) designed to target an integrated reporter and two endogenous rat genes, Immunoglobulin M (IgM) and Rab38,...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Geurts, Aron M., Cost, Gregory J., Freyvert, Yevgeniy, Zeitler, Bryan, Miller, Jeffrey C., Choi, Vivian M., Jenkins, Shirin S., Wood, Adam, Cui, Xiaoxia, Meng, Xiangdong, Vincent, Anna, Lam, Stephen, Michalkiewicz, Mieczyslaw, Schilling, Rebecca, Foeckler, Jamie, Kalloway, Shawn, Weiler, Hartmut, Ménoret, Séverine, Anegon, Ignacio, Davis, Gregory D., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Jacob, Howard J., Buelow, Roland
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831805/
https://ncbi.nlm.nih.gov/pubmed/19628861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1172447
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki