Knockout Rats Produced Using Designed Zinc Finger Nucleases

The toolbox of rat genetics currently lacks the ability to introduce site-directed, heritable mutations into the genome to create knockout animals. Using engineered zinc-finger nucleases (ZFNs) designed to target an integrated reporter and two endogenous rat genes, Immunoglobulin M (IgM) and Rab38,...

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Main Authors: Geurts, Aron M., Cost, Gregory J., Freyvert, Yevgeniy, Zeitler, Bryan, Miller, Jeffrey C., Choi, Vivian M., Jenkins, Shirin S., Wood, Adam, Cui, Xiaoxia, Meng, Xiangdong, Vincent, Anna, Lam, Stephen, Michalkiewicz, Mieczyslaw, Schilling, Rebecca, Foeckler, Jamie, Kalloway, Shawn, Weiler, Hartmut, Ménoret, Séverine, Anegon, Ignacio, Davis, Gregory D., Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Jacob, Howard J., Buelow, Roland
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831805/
https://ncbi.nlm.nih.gov/pubmed/19628861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1172447
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