Site-Specific Editing of the Plasmodium falciparum Genome Using Engineered Zinc-Finger Nucleases

Malaria afflicts over 200 million people worldwide and its most lethal etiologic agent, Plasmodium falciparum, is evolving to resist even the latest-generation therapeutics. Efficient tools for genome-directed investigations of P. falciparum pathogenesis, including drug resistance mechanisms, are cl...

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Bibliografiske detaljer
Main Authors: Straimer, Judith, Lee, Marcus CS, Lee, Andrew H, Zeitler, Bryan, Williams, April E, Pearl, Jocelynn R, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Llinás, Manuel, Urnov, Fyodor D, Fidock, David A
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697006/
https://ncbi.nlm.nih.gov/pubmed/22922501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2143
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