Editing the Plasmodium vivax Genome, Using Zinc-Finger Nucleases

Plasmodium vivax is a major cause of malaria morbidity worldwide yet has remained genetically intractable. To stably modify this organism, we used zinc-finger nucleases (ZFNs), which take advantage of homology-directed DNA repair mechanisms at the site of nuclease action. Using ZFNs specific to the...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Moraes Barros, Roberto R., Straimer, Judith, Sa, Juliana M., Salzman, Rebecca E., Melendez-Muniz, Viviana A., Mu, Jianbing, Fidock, David A., Wellems, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334824/
https://ncbi.nlm.nih.gov/pubmed/25081932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu423
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