Establishment of HIV-1 resistance in CD4(+) T cells by genome editing using zinc-finger nucleases

Homozygosity for the naturally occurring Δ32 deletion in the HIV co-receptor CCR5 confers resistance to HIV-1 infection. We generated an HIV-resistant genotype de novo using engineered zinc-finger nucleases (ZFNs) to disrupt endogenous CCR5. Transient expression of CCR5 ZFNs permanently and specific...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Perez, Elena E, Wang, Jianbin, Miller, Jeffrey C, Jouvenot, Yann, Kim, Kenneth A, Liu, Olga, Wang, Nathaniel, Lee, Gary, Bartsevich, Victor V, Lee, Ya-Li, Guschin, Dmitry Y, Rupniewski, Igor, Waite, Adam J, Carpenito, Carmine, Carroll, Richard G, Orange, Jordan S, Urnov, Fyodor D, Rebar, Edward J, Ando, Dale, Gregory, Philip D, Riley, James L, Holmes, Michael C, June, Carl H
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422503/
https://ncbi.nlm.nih.gov/pubmed/18587387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1410
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados