Establishment of HIV-1 resistance in CD4(+) T cells by genome editing using zinc-finger nucleases

Homozygosity for the naturally occurring Δ32 deletion in the HIV co-receptor CCR5 confers resistance to HIV-1 infection. We generated an HIV-resistant genotype de novo using engineered zinc-finger nucleases (ZFNs) to disrupt endogenous CCR5. Transient expression of CCR5 ZFNs permanently and specific...

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Main Authors: Perez, Elena E, Wang, Jianbin, Miller, Jeffrey C, Jouvenot, Yann, Kim, Kenneth A, Liu, Olga, Wang, Nathaniel, Lee, Gary, Bartsevich, Victor V, Lee, Ya-Li, Guschin, Dmitry Y, Rupniewski, Igor, Waite, Adam J, Carpenito, Carmine, Carroll, Richard G, Orange, Jordan S, Urnov, Fyodor D, Rebar, Edward J, Ando, Dale, Gregory, Philip D, Riley, James L, Holmes, Michael C, June, Carl H
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422503/
https://ncbi.nlm.nih.gov/pubmed/18587387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1410
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