Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases

Gene knockout is the most powerful tool for determining gene function or permanently modifying the phenotypic characteristics of a cell. Existing methods for gene disruption are limited by their efficiency, time to completion, and/or the potential for confounding off-target effects. Here, we demonst...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Santiago, Yolanda, Chan, Edmond, Liu, Pei-Qi, Orlando, Salvatore, Zhang, Lin, Urnov, Fyodor D., Holmes, Michael C., Guschin, Dmitry, Waite, Adam, Miller, Jeffrey C., Rebar, Edward J., Gregory, Philip D., Klug, Aaron, Collingwood, Trevor N.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2299223/
https://ncbi.nlm.nih.gov/pubmed/18359850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800940105
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares