Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases

Gene knockout is the most powerful tool for determining gene function or permanently modifying the phenotypic characteristics of a cell. Existing methods for gene disruption are limited by their efficiency, time to completion, and/or the potential for confounding off-target effects. Here, we demonst...

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Bibliografiske detaljer
Main Authors: Santiago, Yolanda, Chan, Edmond, Liu, Pei-Qi, Orlando, Salvatore, Zhang, Lin, Urnov, Fyodor D., Holmes, Michael C., Guschin, Dmitry, Waite, Adam, Miller, Jeffrey C., Rebar, Edward J., Gregory, Philip D., Klug, Aaron, Collingwood, Trevor N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2299223/
https://ncbi.nlm.nih.gov/pubmed/18359850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800940105
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