Establishment of HIV-1 resistance in CD4(+) T cells by genome editing using zinc-finger nucleases

Homozygosity for the naturally occurring Δ32 deletion in the HIV co-receptor CCR5 confers resistance to HIV-1 infection. We generated an HIV-resistant genotype de novo using engineered zinc-finger nucleases (ZFNs) to disrupt endogenous CCR5. Transient expression of CCR5 ZFNs permanently and specific...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Perez, Elena E, Wang, Jianbin, Miller, Jeffrey C, Jouvenot, Yann, Kim, Kenneth A, Liu, Olga, Wang, Nathaniel, Lee, Gary, Bartsevich, Victor V, Lee, Ya-Li, Guschin, Dmitry Y, Rupniewski, Igor, Waite, Adam J, Carpenito, Carmine, Carroll, Richard G, Orange, Jordan S, Urnov, Fyodor D, Rebar, Edward J, Ando, Dale, Gregory, Philip D, Riley, James L, Holmes, Michael C, June, Carl H
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422503/
https://ncbi.nlm.nih.gov/pubmed/18587387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1410
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky