Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential

AML1-ETO (RUNX1-ETO) fusion proteins are generated by the 8;21 translocation, commonly found in acute myeloid leukemia, which fuses the AML1 (RUNX1) and ETO (MTG8, RUNX1T1) genes. Previous studies have shown that AML1-ETO interferes with AML1 function but requires additional cooperating mutations to...

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Detalhes bibliográficos
Main Authors: DeKelver, Russell C., Yan, Ming, Ahn, Eun-Young, Shia, Wei-Jong, Speck, Nancy A., Zhang, Dong-Er
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643768/
https://ncbi.nlm.nih.gov/pubmed/23426948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-11-465641
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