Structure of the AML1-ETO eTAFH domain–HEB peptide complex and its contribution to AML1-ETO activity

AML1-ETO is the chimeric protein product of the t(8;21) in acute myeloid leukemia. The ETO portion of the fusion protein includes the eTAFH domain, which is homologous to several TATA binding protein–associated factors (TAFs) and interacts with E proteins (E2A and HEB). It has been proposed that AML...

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Detalhes bibliográficos
Main Authors: Park, Sangho, Chen, Wei, Cierpicki, Tomasz, Tonelli, Marco, Cai, Xiongwei, Speck, Nancy A., Bushweller, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668852/
https://ncbi.nlm.nih.gov/pubmed/19204326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-161307
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