Structure of the AML1-ETO Nervy domain – PKA(RIIα) complex and its contribution to AML1-ETO activity

AML1-ETO is the chimeric protein product of the t(8;21) in acute myeloid leukemia. The ETO portion of the fusion protein includes the Nervy Homology Region 3 (NHR3) domain, which shares homology with A-Kinase Anchoring Proteins (AKAPs) and interacts with the regulatory subunit of type II cAMP-depend...

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Main Authors: Corpora, Takeshi, Roudaia, Liya, Oo, Zaw Min, Chen, Wei, Manuylova, Ekaterina, Cai, Xiongwei, Chen, Michael J., Cierpicki, Tomasz, Speck, Nancy A., Bushweller, John H.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945414/
https://ncbi.nlm.nih.gov/pubmed/20708017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.08.007
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