Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity

AML1/ETO results from the t(8;21) associated with 12-15% of acute myeloid leukemia. The AML1/ETO MYND domain mediates interactions with the co-repressors SMRT and N-CoR and contributes to AML1/ETO's ability to repress proliferation and differentiation of primary bone marrow cells as well as to...

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Main Authors: Liu, Yizhou, Chen, Wei, Gaudet, Justin, Cheney, Matthew D., Roudaia, Liya, Cierpicki, Tomasz, Klet, Rachel C., Hartman, Kari, Laue, Thomas M., Speck, Nancy A., Bushweller, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978186/
https://ncbi.nlm.nih.gov/pubmed/17560331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.04.010
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