Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells

BACKGROUND: Many leukemias result from chromosomal rearrangements. The t(8;21) chromosomal translocation produces AML1-ETO, an oncogenic fusion protein that compromises the function of AML1, a transcription factor critical for myeloid cell differentiation. Because of the pressing need for new therap...

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Vydáno v:BMC Genomics
Hlavní autoři: Trombly, Daniel J, Whitfield, Troy W, Padmanabhan, Srivatsan, Gordon, Jonathan AR, Lian, Jane B, van Wijnen, Andre J, Zaidi, Sayyed K, Stein, Janet L, Stein, Gary S
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434520/
https://ncbi.nlm.nih.gov/pubmed/25928846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-1445-0
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