α-Thalassemia, Mental Retardation, and Myelodysplastic Syndrome

Por Gibbons, Richard J.
Publicado em 2012

Maintaining memory of silencing at imprinted differentially methylated regions

Por Voon, Hsiao P. J., Gibbons, Richard J.
Publicado no Cell Mol Life Sci (2016)

α-Globin as a molecular target in the treatment of β-thalassemia

Por Mettananda, Sachith, Gibbons, Richard J., Higgs, Douglas R.
Publicado no Blood (2015)

ATRX Contributes to MeCP2-Mediated Pericentric Heterochromatin Organization during Neural Differentiation

Por Marano, Domenico, Fioriniello, Salvatore, Fiorillo, Francesca, Gibbons, Richard J., D’Esposito, Maurizio, Della Ragione, Floriana
Publicado no Int J Mol Sci (2019)

Neuronal Death Resulting from Targeted Disruption of the Snf2 Protein ATRX Is Mediated by p53

Por Seah, Claudia, Levy, Michael A., Jiang, Yan, Mokhtarzada, Sulayman, Higgs, Douglas R., Gibbons, Richard J., Bérubé, Nathalie G.
Publicado no J Neurosci (2008)

Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX

Por Argentaro, Anthony, Yang, Ji-Chun, Chapman, Lynda, Kowalczyk, Monika S., Gibbons, Richard J., Higgs, Douglas R., Neuhaus, David, Rhodes, Daniela
Publicado em 2007

Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia

Por Mettananda, Sachith, Fisher, Christopher A., Sloane-Stanley, Jackie A., Taylor, Stephen, Oppermann, Udo, Gibbons, Richard J., Higgs, Douglas R.
Publicado no Haematologica (2017)

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

Por Clynes, David, Jelinska, Clare, Xella, Barbara, Ayyub, Helena, Scott, Caroline, Mitson, Matthew, Taylor, Stephen, Higgs, Douglas R., Gibbons, Richard J.
Publicado no Nat Commun (2015)

ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells

Por Clynes, David, Jelinska, Clare, Xella, Barbara, Ayyub, Helena, Taylor, Stephen, Mitson, Matthew, Bachrati, Csanád Z., Higgs, Douglas R., Gibbons, Richard J.
Publicado em 2014

The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis

Por Bérubé, Nathalie G., Mangelsdorf, Marie, Jagla, Magdalena, Vanderluit, Jackie, Garrick, David, Gibbons, Richard J., Higgs, Douglas R., Slack, Ruth S., Picketts, David J.
Publicado em 2005

Loss of Atrx Affects Trophoblast Development and the Pattern of X-Inactivation in Extraembryonic Tissues

Por Garrick, David, Sharpe, Jackie A, Arkell, Ruth, Dobbie, Lorraine, Smith, Andrew J. H, Wood, William G, Higgs, Douglas R, Gibbons, Richard J
Publicado em 2006

Defining the Cause of Skewed X-Chromosome Inactivation in X-Linked Mental Retardation by Use of a Mouse Model

Por Muers, Mary R. , Sharpe, Jacqueline A. , Garrick, David , Sloane-Stanley, Jacqueline , Nolan, Patrick M. , Hacker, Terry , Wood, William G. , Higgs, Douglas R. , Gibbons, Richard J. 
Publicado em 2007

ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes

Por Voon, Hsiao P.J., Hughes, Jim R., Rode, Christina, De La Rosa-Velázquez, Inti A., Jenuwein, Thomas, Feil, Robert, Higgs, Douglas R., Gibbons, Richard J.
Publicado no Cell Rep (2015)

The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening.

Por Kim, Jeongkyu, Sun, Chongkui, Tran, Andy D., Chin, Pei-Ju, Ruiz, Penelope D., Wang, Kun, Gibbons, Richard J., Gamble, Mathew J., Liu, Yie, Oberdoerffer, Philipp
Publicado no Nat Struct Mol Biol (2019)

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

Por Schwab, Rebekka A., Nieminuszczy, Jadwiga, Shah, Fenil, Langton, Jamie, Lopez Martinez, David, Liang, Chih-Chao, Cohn, Martin A., Gibbons, Richard J., Deans, Andrew J., Niedzwiedz, Wojciech
Publicado no Mol Cell (2015)

High-resolution analysis of cis-acting regulatory networks at the α-globin locus

Por Hughes, Jim R., Lower, Karen M., Dunham, Ian, Taylor, Stephen, De Gobbi, Marco, Sloane-Stanley, Jacqueline A., McGowan, Simon, Ragoussis, Jiannis, Vernimmen, Douglas, Gibbons, Richard J., Higgs, Douglas R.
Publicado em 2013

JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response

Por Chen, Edwin, Ahn, Jong Sook, Massie, Charlie E., Clynes, David, Godfrey, Anna L., Li, Juan, Park, Hyun Jung, Nangalia, Jyoti, Silber, Yvonne, Mullally, Ann, Gibbons, Richard J., Green, Anthony R.
Publicado em 2014

Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide Donors

Por Moir-Meyer, Gemma, Cheong, Pak Leng, Olijnik, Aude-Anais, Brown, Jill, Knight, Samantha, King, Andrew, Kurita, Ryo, Nakamura, Yukio, Gibbons, Richard J., Higgs, Douglas R., Buckle, Veronica J., Babbs, Christian
Publicado no Methods Protoc (2018)

Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition

Por Lower, Karen M., Hughes, Jim R., De Gobbi, Marco, Henderson, Shirley, Viprakasit, Vip, Fisher, Chris, Goriely, Anne, Ayyub, Helena, Sloane-Stanley, Jackie, Vernimmen, Douglas, Langford, Cordelia, Garrick, David, Gibbons, Richard J., Higgs, Douglas R.
Publicado em 2009

Persistence of skewed X-chromosome inactivation in pre-B acute lymphoblastic leukemia of a female ATRX mutation carrier

Por Bradley, Christian P., Chen, Cai, Oetjen, Karolyn A., Yan, Cheng, Panjwani, Reema, Hauffe, Sara, Calvo, Katherine R., Yuan, Constance, Patel, Prapti Arvind, Montgomery, Nathan D., Foster, Matthew C., Battiwalla, Minoo, Barrett, A. John, Gibbons, Richard J., Ito, Sawa
Publicado no Blood Adv (2019)