Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition

It is well established that all of the cis-acting sequences required for fully regulated human α-globin expression are contained within a region of ≈120 kb of conserved synteny. Here, we show that activation of this cluster in erythroid cells dramatically affects expression of apparently unrelated a...

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Bibliographic Details
Main Authors: Lower, Karen M., Hughes, Jim R., De Gobbi, Marco, Henderson, Shirley, Viprakasit, Vip, Fisher, Chris, Goriely, Anne, Ayyub, Helena, Sloane-Stanley, Jackie, Vernimmen, Douglas, Langford, Cordelia, Garrick, David, Gibbons, Richard J., Higgs, Douglas R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799829/
https://ncbi.nlm.nih.gov/pubmed/19959666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909331106
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