The role of the polycomb complex in silencing α-globin gene expression in nonerythroid cells

Although much is known about globin gene activation in erythroid cells, relatively little is known about how these genes are silenced in nonerythroid tissues. Here we show that the human α- and β-globin genes are silenced by fundamentally different mechanisms. The α-genes, which are surrounded by wi...

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Detalhes bibliográficos
Main Authors: Garrick, David, De Gobbi, Marco, Samara, Vasiliki, Rugless, Michelle, Holland, Michelle, Ayyub, Helena, Lower, Karen, Sloane-Stanley, Jackie, Gray, Nicki, Koch, Christoph, Dunham, Ian, Higgs, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Red Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572806/
https://ncbi.nlm.nih.gov/pubmed/18689541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-161901
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