Uncovering Enhancer Functions Using the α-Globin Locus

par Vernimmen, Douglas
Publié 2014

The complexity of epigenetic diseases

par Brazel, Ailbhe Jane, Vernimmen, Douglas
Publié dans J Pathol (2015)

Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping

par Kernohan, Kristin D., Vernimmen, Douglas, Gloor, Gregory B., Bérubé, Nathalie G.
Publié 2014

Identification of HTF (HER2 transcription factor) as an AP-2 (activator protein-2) transcription factor and contribution of the HTF binding site to ERBB2 gene overexpression.

par Vernimmen, Douglas, Begon, Dominique, Salvador, Christophe, Gofflot, Stéphanie, Grooteclaes, Madeleine, Winkler, Rosita
Publié 2003

Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression

par Vernimmen, Douglas, Gobbi, Marco De, Sloane-Stanley, Jacqueline A, Wood, William G, Higgs, Douglas R
Publié 2007

CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands

par van de Lagemaat, Louie N., Flenley, Maria, Lynch, Magnus D., Garrick, David, Tomlinson, Simon R., Kranc, Kamil R., Vernimmen, Douglas
Publié dans Epigenetics Chromatin (2018)

Alveolar Macrophage Chromatin Is Modified to Orchestrate Host Response to Mycobacterium bovis Infection

par Hall, Thomas J., Vernimmen, Douglas, Browne, John A., Mullen, Michael P., Gordon, Stephen V., MacHugh, David E., O’Doherty, Alan M.
Publié dans Front Genet (2020)

Polycomb eviction as a new distant enhancer function

par Vernimmen, Douglas, Lynch, Magnus D., De Gobbi, Marco, Garrick, David, Sharpe, Jacqueline A., Sloane-Stanley, Jacqueline A., Smith, Andrew J.H., Higgs, Douglas R.
Publié 2011

High-resolution analysis of cis-acting regulatory networks at the α-globin locus

par Hughes, Jim R., Lower, Karen M., Dunham, Ian, Taylor, Stephen, De Gobbi, Marco, Sloane-Stanley, Jacqueline A., McGowan, Simon, Ragoussis, Jiannis, Vernimmen, Douglas, Gibbons, Richard J., Higgs, Douglas R.
Publié 2013

Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition

par Lower, Karen M., Hughes, Jim R., De Gobbi, Marco, Henderson, Shirley, Viprakasit, Vip, Fisher, Chris, Goriely, Anne, Ayyub, Helena, Sloane-Stanley, Jackie, Vernimmen, Douglas, Langford, Cordelia, Garrick, David, Gibbons, Richard J., Higgs, Douglas R.
Publié 2009

Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells

par Funnell, Alister PW, Vernimmen, Douglas, Lim, Wooi F, Mak, Ka Sin, Wienert, Beeke, Martyn, Gabriella E, Artuz, Crisbel M, Burdach, Jon, Quinlan, Kate GR, Higgs, Douglas R, Whitelaw, Emma, Pearson, Richard CM, Crossley, Merlin
Publié 2014

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

par Lynch, Magnus D, Smith, Andrew J H, De Gobbi, Marco, Flenley, Maria, Hughes, Jim R, Vernimmen, Douglas, Ayyub, Helena, Sharpe, Jacqueline A, Sloane-Stanley, Jacqueline A, Sutherland, Linda, Meek, Stephen, Burdon, Tom, Gibbons, Richard J, Garrick, David, Higgs, Douglas R
Publié 2012

Generation of bivalent chromatin domains during cell fate decisions

par De Gobbi, Marco, Garrick, David, Lynch, Magnus, Vernimmen, Douglas, Hughes, Jim R, Goardon, Nicolas, Luc, Sidinh, Lower, Karen M, Sloane-Stanley, Jacqueline A, Pina, Cristina, Soneji, Shamit, Renella, Raffaele, Enver, Tariq, Taylor, Stephen, Jacobsen, Sten Eirik W, Vyas, Paresh, Gibbons, Richard J, Higgs, Douglas R
Publié 2011

The STAT3-IL10-IL6 pathway is a novel regulator of macrophage efferocytosis and phenotypic conversion in sterile liver injury

par Campana, Lara, Starkey Lewis, Philip J., Pellicoro, Antonella, Aucott, Rebecca L., Man, Janet, O'Duibhir, Eoghan, Mok, Sarah E., Ferreira-Gonzalez, Sofia, Livingstone, Eilidh, Greenhalgh, Stephen N., Hull, Katherine L, Kendall, Timothy J., Vernimmen, Douglas, Henderson, Neil C., Boulter, Luke, Gregory, Christopher D., Feng, Yi, Anderton, Stephen M., Forbes, Stuart J., Iredale, John P.
Publié dans J Immunol (2017)

JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells

par Lawson, Hannah, Sepulveda, Catarina, van de Lagemaat, Louie N., Durko, Jozef, Barile, Melania, Tavosanis, Andrea, Georges, Elise, Shmakova, Alena, Timms, Penny, Carter, Roderick N., Allen, Lewis, Campos, Joana, Vukovic, Milica, Guitart, Amelie V., Giles, Peter, O’Shea, Marie, Vernimmen, Douglas, Morton, Nicholas M., Rodrigues, Neil P., Göttgens, Berthold, Schofield, Christopher J., Lengeling, Andreas, O’Carroll, Dónal, Kranc, Kamil R.
Publié dans Blood Adv (2021)

Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

par Paris, Jasmin, Morgan, Marcos, Campos, Joana, Spencer, Gary J., Shmakova, Alena, Ivanova, Ivayla, Mapperley, Christopher, Lawson, Hannah, Wotherspoon, David A., Sepulveda, Catarina, Vukovic, Milica, Allen, Lewis, Sarapuu, Annika, Tavosanis, Andrea, Guitart, Amelie V., Villacreces, Arnaud, Much, Christian, Choe, Junho, Azar, Ali, van de Lagemaat, Louie N., Vernimmen, Douglas, Nehme, Ali, Mazurier, Frederic, Somervaille, Tim C.P., Gregory, Richard I., O’Carroll, Dónal, Kranc, Kamil R.
Publié dans Cell Stem Cell (2019)

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions

par Guitart, Amelie V., Panagopoulou, Theano I., Villacreces, Arnaud, Vukovic, Milica, Sepulveda, Catarina, Allen, Lewis, Carter, Roderick N., van de Lagemaat, Louie N., Morgan, Marcos, Giles, Peter, Sas, Zuzanna, Gonzalez, Marta Vila, Lawson, Hannah, Paris, Jasmin, Edwards-Hicks, Joy, Schaak, Katrin, Subramani, Chithra, Gezer, Deniz, Armesilla-Diaz, Alejandro, Wills, Jimi, Easterbrook, Aaron, Coman, David, So, Chi Wai Eric, O’Carroll, Donal, Vernimmen, Douglas, Rodrigues, Neil P., Pollard, Patrick J., Morton, Nicholas M., Finch, Andrew, Kranc, Kamil R.
Publié dans J Exp Med (2017)