Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions

Strict regulation of stem cell metabolism is essential for tissue functions and tumor suppression. In this study, we investigated the role of fumarate hydratase (Fh1), a key component of the mitochondrial tricarboxylic acid (TCA) cycle and cytosolic fumarate metabolism, in normal and leukemic hemato...

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書誌詳細
出版年:J Exp Med
主要な著者: Guitart, Amelie V., Panagopoulou, Theano I., Villacreces, Arnaud, Vukovic, Milica, Sepulveda, Catarina, Allen, Lewis, Carter, Roderick N., van de Lagemaat, Louie N., Morgan, Marcos, Giles, Peter, Sas, Zuzanna, Gonzalez, Marta Vila, Lawson, Hannah, Paris, Jasmin, Edwards-Hicks, Joy, Schaak, Katrin, Subramani, Chithra, Gezer, Deniz, Armesilla-Diaz, Alejandro, Wills, Jimi, Easterbrook, Aaron, Coman, David, So, Chi Wai Eric, O’Carroll, Donal, Vernimmen, Douglas, Rodrigues, Neil P., Pollard, Patrick J., Morton, Nicholas M., Finch, Andrew, Kranc, Kamil R.
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2017
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339674/
https://ncbi.nlm.nih.gov/pubmed/28202494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161087
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