Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM). Knockdown of key mediators of cellular responses to hypoxia with shRNA, namely hypoxia-inducible factor-1α (HIF-1α) or HIF-2α, in human acute myeloid leukemia (AML) samples results in their apoptosis and inability to engraft...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Vukovic, Milica, Guitart, Amelie V., Sepulveda, Catarina, Villacreces, Arnaud, O'Duibhir, Eoghan, Panagopoulou, Theano I., Ivens, Alasdair, Menendez-Gonzalez, Juan, Iglesias, Juan Manuel, Allen, Lewis, Glykofrydis, Fokion, Subramani, Chithra, Armesilla-Diaz, Alejandro, Post, Annemarie E.M., Schaak, Katrin, Gezer, Deniz, So, Chi Wai Eric, Holyoake, Tessa L., Wood, Andrew, O'Carroll, Dónal, Ratcliffe, Peter J., Kranc, Kamil R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689165/
https://ncbi.nlm.nih.gov/pubmed/26642852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150452
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