Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM). Knockdown of key mediators of cellular responses to hypoxia with shRNA, namely hypoxia-inducible factor-1α (HIF-1α) or HIF-2α, in human acute myeloid leukemia (AML) samples results in their apoptosis and inability to engraft...

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書誌詳細
出版年:J Exp Med
主要な著者: Vukovic, Milica, Guitart, Amelie V., Sepulveda, Catarina, Villacreces, Arnaud, O'Duibhir, Eoghan, Panagopoulou, Theano I., Ivens, Alasdair, Menendez-Gonzalez, Juan, Iglesias, Juan Manuel, Allen, Lewis, Glykofrydis, Fokion, Subramani, Chithra, Armesilla-Diaz, Alejandro, Post, Annemarie E.M., Schaak, Katrin, Gezer, Deniz, So, Chi Wai Eric, Holyoake, Tessa L., Wood, Andrew, O'Carroll, Dónal, Ratcliffe, Peter J., Kranc, Kamil R.
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2015
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689165/
https://ncbi.nlm.nih.gov/pubmed/26642852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150452
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