HIF-2α, but not HIF-1α, promotes iron absorption in mice

HIF transcription factors (HIF-1 and HIF-2) are central mediators of cellular adaptation to hypoxia. Because the resting partial pressure of oxygen is low in the intestinal lumen, epithelial cells are believed to be mildly hypoxic. Having recently established a link between HIF and the iron-regulato...

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Main Authors: Mastrogiannaki, Maria, Matak, Pavle, Keith, Brian, Simon, M. Celeste, Vaulont, Sophie, Peyssonnaux, Carole
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673882/
https://ncbi.nlm.nih.gov/pubmed/19352007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38499
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