Copper Deficiency Leads to Anemia, Duodenal Hypoxia, Upregulation of HIF-2α and Altered Expression of Iron Absorption Genes in Mice

Iron and copper are essential trace metals, actively absorbed from the proximal gut in a regulated fashion. Depletion of either metal can lead to anemia. In the gut, copper deficiency can affect iron absorption through modulating the activity of hephaestin - a multi-copper oxidase required for optim...

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Hauptverfasser: Matak, Pavle, Zumerle, Sara, Mastrogiannaki, Maria, El Balkhi, Souleiman, Delga, Stephanie, Mathieu, Jacques R. R., Canonne-Hergaux, François, Poupon, Joel, Sharp, Paul A., Vaulont, Sophie, Peyssonnaux, Carole
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610650/
https://ncbi.nlm.nih.gov/pubmed/23555700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059538
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