Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

BACKGROUND: Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected. We previously reported that in mice in which both liver hypoxia-inducible factors-1 and -2 are stabilized (the hepatocyte von Hippel-Linda...

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Detalhes bibliográficos
Main Authors: Mastrogiannaki, Maria, Matak, Pavle, Mathieu, Jacques R.R., Delga, Stéphanie, Mayeux, Patrick, Vaulont, Sophie, Peyssonnaux, Carole
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2012
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366646/
https://ncbi.nlm.nih.gov/pubmed/22207682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.056119
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