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Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis
BACKGROUND: Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected. We previously reported that in mice in which both liver hypoxia-inducible factors-1 and -2 are stabilized (the hepatocyte von Hippel-Linda...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Ferrata Storti Foundation
2012
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366646/ https://ncbi.nlm.nih.gov/pubmed/22207682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.056119 |
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