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Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis
Iron demand in bone marrow increases when erythropoiesis is stimulated by hypoxia via increased erythropoietin (EPO) synthesis in kidney and liver. Hepcidin, a small polypeptide produced by hepatocytes, plays a central role in regulating iron uptake by promoting internalization and degradation of fe...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3533545/ https://ncbi.nlm.nih.gov/pubmed/23114598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63924 |
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