Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin

The adult kidney plays a central role in erythropoiesis and is the main source of erythropoietin (EPO), an oxygen-sensitive glycoprotein that is essential for red blood cell production. Decreases of renal pO(2) promote hypoxia-inducible factor 2–mediated (HIF-2–mediated) induction of EPO in peritubu...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Farsijani, Navid M., Liu, Qingdu, Kobayashi, Hanako, Davidoff, Olena, Sha, Feng, Fandrey, Joachim, Ikizler, T. Alp, O’Connor, Paul M., Haase, Volker H.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811147/
https://ncbi.nlm.nih.gov/pubmed/26927670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74997
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