Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin

Renal peritubular interstitial fibroblast-like cells are critical for adult erythropoiesis, as they are the main source of erythropoietin (EPO). Hypoxia-inducible factor 2 (HIF-2) controls EPO synthesis in the kidney and liver and is regulated by prolyl-4-hydroxylase domain (PHD) dioxygenases PHD1,...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Kobayashi, Hanako, Liu, Qingdu, Binns, Thomas C., Urrutia, Andres A., Davidoff, Olena, Kapitsinou, Pinelopi P., Pfaff, Andrew S., Olauson, Hannes, Wernerson, Annika, Fogo, Agnes B., Fong, Guo-Hua, Gross, Kenneth W., Haase, Volker H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855934/
https://ncbi.nlm.nih.gov/pubmed/27088801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83551
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