Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells

BACKGROUND: Krüppel-like Factor 3 (KLF3) is a broadly expressed zinc-finger transcriptional repressor with diverse biological roles. During erythropoiesis, KLF3 acts as a feedback repressor of a set of genes that are activated by Krüppel-like Factor 1 (KLF1). Noting that KLF1 binds α-globin gene reg...

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Detalhes bibliográficos
Main Authors: Funnell, Alister PW, Vernimmen, Douglas, Lim, Wooi F, Mak, Ka Sin, Wienert, Beeke, Martyn, Gabriella E, Artuz, Crisbel M, Burdach, Jon, Quinlan, Kate GR, Higgs, Douglas R, Whitelaw, Emma, Pearson, Richard CM, Crossley, Merlin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033687/
https://ncbi.nlm.nih.gov/pubmed/24885809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-15-8
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