Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor

Transcription factors (TFs) are often regarded as being composed of a DNA-binding domain (DBD) and a functional domain. The two domains are considered separable and autonomous, with the DBD directing the factor to its target genes and the functional domain imparting transcriptional regulation. We ex...

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Main Authors: Burdach, Jon, Funnell, Alister P. W., Mak, Ka Sin, Artuz, Crisbel M., Wienert, Beeke, Lim, Wooi F., Tan, Lit Yeen, Pearson, Richard C. M., Crossley, Merlin
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Gene Regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874204/
https://ncbi.nlm.nih.gov/pubmed/24106088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt895
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