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Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain
Transcription factors are often regarded as having two separable components: a DNA-binding domain (DBD) and a functional domain (FD), with the DBD thought to determine target gene recognition. While this holds true for DNA binding in vitro, it appears that in vivo FDs can also influence genomic targ...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4838343/ https://ncbi.nlm.nih.gov/pubmed/26673701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1380 |
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