Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain

Transcription factors are often regarded as having two separable components: a DNA-binding domain (DBD) and a functional domain (FD), with the DBD thought to determine target gene recognition. While this holds true for DNA binding in vitro, it appears that in vivo FDs can also influence genomic targ...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Lim, Wooi F., Burdach, Jon, Funnell, Alister P.W., Pearson, Richard C.M., Quinlan, Kate G.R., Crossley, Merlin
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Gene regulation, Chromatin and Epigenetics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838343/
https://ncbi.nlm.nih.gov/pubmed/26673701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1380
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