Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain

Transcription factors are often regarded as having two separable components: a DNA-binding domain (DBD) and a functional domain (FD), with the DBD thought to determine target gene recognition. While this holds true for DNA binding in vitro, it appears that in vivo FDs can also influence genomic targ...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Lim, Wooi F., Burdach, Jon, Funnell, Alister P.W., Pearson, Richard C.M., Quinlan, Kate G.R., Crossley, Merlin
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838343/
https://ncbi.nlm.nih.gov/pubmed/26673701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1380
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