Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor

Transcription factors (TFs) are often regarded as being composed of a DNA-binding domain (DBD) and a functional domain. The two domains are considered separable and autonomous, with the DBD directing the factor to its target genes and the functional domain imparting transcriptional regulation. We ex...

Full description

Saved in:
Bibliographic Details
Main Authors: Burdach, Jon, Funnell, Alister P. W., Mak, Ka Sin, Artuz, Crisbel M., Wienert, Beeke, Lim, Wooi F., Tan, Lit Yeen, Pearson, Richard C. M., Crossley, Merlin
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874204/
https://ncbi.nlm.nih.gov/pubmed/24106088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt895
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items