Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells

BACKGROUND: Krüppel-like Factor 3 (KLF3) is a broadly expressed zinc-finger transcriptional repressor with diverse biological roles. During erythropoiesis, KLF3 acts as a feedback repressor of a set of genes that are activated by Krüppel-like Factor 1 (KLF1). Noting that KLF1 binds α-globin gene reg...

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Main Authors: Funnell, Alister PW, Vernimmen, Douglas, Lim, Wooi F, Mak, Ka Sin, Wienert, Beeke, Martyn, Gabriella E, Artuz, Crisbel M, Burdach, Jon, Quinlan, Kate GR, Higgs, Douglas R, Whitelaw, Emma, Pearson, Richard CM, Crossley, Merlin
格式: Artigo
語言:Inglês
出版: BioMed Central 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033687/
https://ncbi.nlm.nih.gov/pubmed/24885809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-15-8
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