Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch

The Krüppel-like factor (KLF) family of transcription factors play critical roles in haematopoiesis. KLF1, the founding member of the family, has been implicated in the control of both erythropoiesis and megakaryopoiesis. Here we describe a novel system using an artificial dominant negative isoform...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Norton, Laura J., Hallal, Samantha, Stout, Elizabeth S., Funnell, Alister P. W., Pearson, Richard C. M., Crossley, Merlin, Quinlan, Kate G. R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466599/
https://ncbi.nlm.nih.gov/pubmed/28600522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03289-5
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