Generation of bivalent chromatin domains during cell fate decisions

BACKGROUND: In self-renewing, pluripotent cells, bivalent chromatin modification is thought to silence (H3K27me3) lineage control genes while 'poising' (H3K4me3) them for subsequent activation during differentiation, implying an important role for epigenetic modification in directing cell...

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Autors principals: De Gobbi, Marco, Garrick, David, Lynch, Magnus, Vernimmen, Douglas, Hughes, Jim R, Goardon, Nicolas, Luc, Sidinh, Lower, Karen M, Sloane-Stanley, Jacqueline A, Pina, Cristina, Soneji, Shamit, Renella, Raffaele, Enver, Tariq, Taylor, Stephen, Jacobsen, Sten Eirik W, Vyas, Paresh, Gibbons, Richard J, Higgs, Douglas R
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131236/
https://ncbi.nlm.nih.gov/pubmed/21645363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-4-9
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