JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells

Lifelong multilineage hematopoiesis critically depends on rare hematopoietic stem cells (HSCs) that reside in the hypoxic bone marrow microenvironment. Although the role of the canonical oxygen sensor hypoxia-inducible factor prolyl hydroxylase has been investigated extensively in hematopoiesis, the...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Lawson, Hannah, Sepulveda, Catarina, van de Lagemaat, Louie N., Durko, Jozef, Barile, Melania, Tavosanis, Andrea, Georges, Elise, Shmakova, Alena, Timms, Penny, Carter, Roderick N., Allen, Lewis, Campos, Joana, Vukovic, Milica, Guitart, Amelie V., Giles, Peter, O’Shea, Marie, Vernimmen, Douglas, Morton, Nicholas M., Rodrigues, Neil P., Göttgens, Berthold, Schofield, Christopher J., Lengeling, Andreas, O’Carroll, Dónal, Kranc, Kamil R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2021
Schlagworte:
Hematopoiesis and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876897/
https://ncbi.nlm.nih.gov/pubmed/33560400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002702
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