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The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening.
The growth of telomerase-deficient cancers depends on the alternative lengthening of telomeres (ALT), a homology-directed telomere maintenance pathway. ALT telomeres exhibit a unique chromatin environment and generally lack the nucleosome remodeler ATRX, pointing to an epigenetic basis for ALT. Rece...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6537592/ https://ncbi.nlm.nih.gov/pubmed/30833786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0192-3 |
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