The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening.

The growth of telomerase-deficient cancers depends on the alternative lengthening of telomeres (ALT), a homology-directed telomere maintenance pathway. ALT telomeres exhibit a unique chromatin environment and generally lack the nucleosome remodeler ATRX, pointing to an epigenetic basis for ALT. Rece...

詳細記述

保存先:
書誌詳細
出版年:Nat Struct Mol Biol
主要な著者: Kim, Jeongkyu, Sun, Chongkui, Tran, Andy D., Chin, Pei-Ju, Ruiz, Penelope D., Wang, Kun, Gibbons, Richard J., Gamble, Mathew J., Liu, Yie, Oberdoerffer, Philipp
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537592/
https://ncbi.nlm.nih.gov/pubmed/30833786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0192-3
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