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SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing

Myelodysplastic syndromes (MDS) are a group of neoplasms characterized by ineffective myeloid hematopoiesis and various risks for leukemia. SRSF2, a member of the serine/arginine-rich (SR) family of splicing factors, is one of the mutation targets associated with poor survival in patients suffering...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Komeno, Yukiko, Huang, Yi-Jou, Qiu, Jinsong, Lin, Leo, Xu, YiJun, Zhou, Yu, Chen, Liang, Monterroza, Dora D., Li, Hairi, DeKelver, Russell C., Yan, Ming, Fu, Xiang-Dong, Zhang, Dong-Er
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525309/
https://ncbi.nlm.nih.gov/pubmed/26124281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00202-15
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